| 抗体名称 | Anti-CXCR4 Antibody |
| 指标别名 | CD184;CXC R4;CXCR 4;CXCR4;CXCR4B;D2S201E;FB22;Fusin;HM89;HSY3RR;LAP3;LCR1;LESTR;SDF 1 receptor;WHIM |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IP,IF,FCM,IHC |
| 基因名称 | CXCR4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-CXCR4 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4 isoform b.The immunogen is located within the first 50 amino acids of CXCR4. |
| 计算分子量 | 40kDa |
| 成分 | CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | CXCR4 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | CXCR4,a G-protein coupled receptor (GPCR) with seven transmembrane domains,is a CXC chemokine receptor specific for stromal-derived-factor-1 (SDF-1 or CXCL12).CXCR4 was initially discovered as one of the co-receptors for HIV entry into CD4+ T cells (1).Blocking CXCR4 could be potentially used as novel therapeutics for HIV treatment. CXCR4 signaling plays an important role in the migration,proliferation and quiescence of hematopoietic stem cell and their retention within the bone marrow,where it has high levels of SDF-1/CXCL12(2).It has been demonstrated that CXCR4 signaling mediates CD20 up-regulation on B cells (3). CXCR4 is highly expressed in more than 23 types of cancer,including breast cancer,ovarian cancer,melanoma,and prostate cancer,while there is very less or no expression of CXCR4 in healthy tissues.CXCR4 expression in cancer cells has been reported to be associated with tumor survival,growth and metastasis in tissues with high levels of SDF-1/CXCL12,such as lungs,liver and bone marrow (4,5). CXCR4 has been shown to regulate neuronal migration,cell positioning and axon wiring (6,7).CXCR4 mutant mice displayed aberrant neuronal distribution,which implicates the role in neuronal disorders such as epilepsy.CXCR4 is also involved in WHIM syndrome (8).WHIM mutations in CXCR4 were recently found in patients with Waldenstrom's macroglobulinemia,and these mutations are correlated to clinical resistance to ibrutinib (9,10). |
| Uniprot ID | P61073 |
| 基因名全称 | Chemokine (C-X-C motif) receptor 4 |
| 蛋白名全称 | Chemokine (C-X-C motif) receptor 4 |
| 推荐稀释比 | WB:1 ～ 2μg/mL;IP/ICC:2μg/mL;IHC:5μg/mL;IF:20μg/mL;Flow Cyt:0.1μg/mL.Antibody validated:Western Blot in human,mouse,and rat samples;Immunohistochemistry,Immunocytochemistry and Immunofluorescence in human samples;Flow Cytometry in human and mouse samples.All other applications and species not yet tested. |
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